The NIH’s High-Risk, High-Reward Research program (HRHR) has the potential to overturn fundamental paradigms, but historically the applicant and awardee pools have not fully represented the demographic and geographic diversity across the U.S. biomedical workforce, says the NIH’s deputy director for extramural research. Those concerns, and others about bias in the peer review process, have led to a new approach — the HRHR program is going to anonymize the review of the Transformative Research Award applications.