To expand the innovation capacity in the nation, the United States needs to leverage resources, creativity, and ingenuity from across all geographic regions. The National Science Foundation this week announced a new program in support of these efforts: the NSF Regional Innovation Engines, or NSF Engines program. This program encourages the creation of regional coalitions of industry, academia, government, nonprofits, civil society, and communities of practice to form partnerships that boost scientific and technological innovation and benefit the economy in a geographic region. Specifically, the NSF Engines program targets geographic areas in the U.S. that lack well-established innovation ecosystems. Awards of up to $160 million for up to 10 years ultimately will be provided. At SSTI’s Annual Conference this week, attendees learned more about this program from NSF representatives.