Over the past decade, two ideas have become more and more popular among innovation and economic development leaders. First, that maximizing collaboration between institutions, interest groups, stakeholders and communities is pivotal in building an innovation ecosystem that can succeed and grow over time. Second, that proximity matters, and by focusing on innovation networks at the regional or metro scale, rather than at the national or state level, initiatives can have a real, measurable economic impact. Though they seem complementary, these ideas are frequently in tension. The first suggests that increasing the number of partners leads to more successful initiatives. The second suggests that, at least in terms of geography, there should be some kind of limit on the scope of innovation initiatives in order to tailor them to the needs of a specific region.