In addition to the Office of Science and Technology (OSTP) report mentioned above, Science: A New Golden Age—which is predominantly about federal policy and approach to advancing AI in an effort to outcompete China for leadership in the platform technology—several other federal agencies made funding announcements Wednesday regarding their own contributions and future commitments to the government-wide Genesis Mission.
All of the announcements were part of the Genesis Mission 2026 Summit. Foremost among them was the Department of Energy’s announcement of 278 awards sharing up to $5 billion in the first round of funding to address the 26 National Science and Technology Challenges released in February. Eighty-seven of the selected projects are led by DOE and National Nuclear Security Administration (NNSA) National Laboratories, 168 are led by universities, 19 are led by companies, and 4 are led by nonprofit organizations. Across the pool are 342 participating institutions: 16 DOE and NNSA National Laboratories, 142 universities, 157 companies, 13 nonprofit organizations, and 14 other institutions.
In its contribution to the summit, the National Science Foundation announced an award of $400 million over four years to support 20 AI-programmable cloud laboratories across the country and $83 million to support six for integrated data systems and services (IDSS) centers and planning grants for potentially more. NSF also announced a $100 million funding opportunity to support AI dataset development with proposals due November 4, 2026
The National Institutes of Health announced its contribution would be Bio Genesis, providing support to advance science addressing six new National Science and Technology Challenges:
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Predicting living systems: Using AI to model and forecast the behavior of complex biological systems
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Scaling biology for American industrial leadership: Accelerating the path from biological discovery to domestic biomanufacturing
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Early detection and attribution of biological threats: Strengthening national biosecurity and biosurveillance capabilities
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Unlocking cures for pediatric cancer through artificial intelligence: Applying AI to accelerate research on childhood cancers
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Accelerating drug discovery and clinical translation: Shortening the timeline from discovery to treatment
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Understanding the root causes of chronic disease: Using AI and advanced data resources to investigate the drivers of chronic illness.
The Department of War (Defense) stated in conjunction with the summit that it is on track to commit over $200 million in funding across Fiscal Year (FY) 2026 and over $1.3 billion in FY 2027 to advance critical National Science & Technology Challenges. A cornerstone of the Department of War's financial commitment is the Digital Biosecurity Forge (DB-FORGE) project, a high-performance computing environment developed in partnership with Lawrence Livermore National Laboratory. This represents a significant investment, starting with $30 million in FY 2026 and projected to scale to $150 million in FY 2027.
The Genesis Mission was announced in Executive Order 4363 on November 24, 2025, calling for the country to secure “global technology dominance in the development of artificial intelligence, an important frontier of scientific discovery and economic growth.”