Three recent reports from Maine provide insight into the challenges of fostering an innovative economy in a rural state. Overall, the research suggests that Maine has done well in its efforts to support startups, but could do more to help those startups expand and find new markets. By encouraging innovation-based businesses to expand to markets outside of Maine and by offering mentoring services, the state could overcome the stagnation that can occur when companies and states focus on local markets.

Graduates of Michigan State University, the University of Michigan and Wayne State University have started or acquired businesses at double the national average rate among college graduates since 1996, according to a report released by the Michigan University Research Corridor (URC). About 19 percent of all graduates have started their own business, and these businesses were 1.5 times more likely than the national average to remain open over the past five years. URC attributes their success to the comprehensive entrepreneurial curriculum available at the corridor's institutions.

U.S. spending on higher education research and development (R&D) declined in FY12 (after adjustments for inflation) for the first time in almost 40 years, according to data from the National Science Foundation (NSF). The decrease marks the end of a period of modest growth since 2009 in which R&D expenditures increased at an average of five percent each year. While data on higher education R&D spending by state is not yet available for FY12, NSF has released state data through FY11, including expenditures by funding source

A recent report from the Intellectual Property Association revealed the top 300 organizations granted U.S. patents in 2010. IBM, Samsung and Microsoft led this year's list. Fourteen universities, including 13 U.S. institutions and one from China, made the top 300, according to The Chronicle of Higher Education. Leading universities include the University of California Regents, the Massachusetts Institute of Technology and Stanford University.

Rice University's Rice Alliance for Technology and Entrepreneurship has been named the top university business incubator in the world by the University Business Incubator (UBI) Index based in Sweden. The group reviewed 550 university business incubators and studied 150 incubators to determine the top incubators in the world based on their value for the ecosystem, their value for clients, and their attraction rate and past performance. Other U.S.