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The health and potential of a state's innovation ecosystem does not always directly correlate to current economic performance and overall job creation, despite media and policymakers' focus on such metrics. Although they vary across organizations and in scope, indices serve to assess states' assets and processes within their innovation ecosystems.

Massachusetts continues to be the country's most successful high-tech economy, according to the 2010 edition of the Milken Institute State Technology and Science Index: Enduring Lessons for the Intangible Economy. The Index uses 79 indicators to evaluate and rank state performance in five categories: R&D inputs, risk capital and entrepreneurial infrastructure, human capital capacity, technology and science workforce, and technology concentration and dynamism.