In an hours-long virtual workshop that could have covered days, the presidents of the National Academies of Sciences, Engineering, and Medicine and leaders from government, academia, and publishing explored key questions the research enterprise must address to build a more effective and resilient 21st century research university. Facing challenges that may have long been present but have been exacerbated and accelerated by the COVID-19 crisis, the leaders began exploring questions that could help research universities rebound to a better place than the pre-pandemic status quo.