A recent Office of Science and Technology Policy (OSTP) memorandum instructs major federal research agencies to provide open access to federally funded research and digital scientific data. All federal agencies with an extramural research budget that exceeds $100 million will participate, following the example of the National Institutes of Health (NIH), which implemented a similar policy in 2008. Over the next six months, these agencies will draft plans to ensure that any results of federal research published in peer-reviewed scholarly publications are available to the public. Depending on implementation, open access could lower overhead costs for research projects, accelerate scientific discovery and create new opportunities for entrepreneurs who organize, analyze and curate large data sets.