The U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) has awarded almost $54 million in grants to 13 projects to conduct research and develop testbeds in response to challenges from the COVID-19 pandemic. The American Rescue Act provided the funding for these awards, which will support projects at eight manufacturing institutes within the Manufacturing USA network. The awarded manufacturing institutions anticipate producing personal protective equipment (PPE) and medical equipment; creating sustainable domestic supply chains; increasing the resiliency of existing supply chains; producing novel COVID-19 tests; providing shared equipment and facilities; producing health alert systems; and, training a new generation of manufacturing workers.