The President’s Council of Advisors on Science and Technology (PCAST) is recommending a set of bold actions to help ensure continued American leadership in Industries of the Future (IotF), comprising artificial intelligence (AI), quantum information science (QIS), advanced manufacturing, advanced communications, and biotechnology. The three pillars underpinning these actions are: enhancing multi-sector engagement in research and innovation; creating a new institute structure that integrates one or more of the IotF areas and spans discovery research to product development; and ensuring the availability of a qualified, diverse IotF workforce.