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While California and Massachusetts may overshadow much of the venture capital (VC) activity going on around the country, other states have made significant progress in developing venture industries that serve the needs of their economy. Though larger investments in later-stage companies are becoming more prevalent in the U.S. venture industry, some states are seeing increases in smaller, early-stage investments that, if successful, should lead to significant growth in their total VC investment in years to come.

Our German isn't what it should be and online translators weren't as helpful as we'd expected, but we wanted to make readers aware of the size of the investment Berlin is making over the next four years to recruit star faculty to its four research universities and the four local, private research institutions of Fraunhofer Gesellschaft, Helmholtzgemeinschaft, Leibniz Community, and the Max Planck Society.

With the recent news that initial public offerings and mergers and acquisitions for venture-back companies are becoming scarce, many are anticipating a national venture capital crisis. A lack of exit opportunities could lead angel and venture investors to become more hesitant to invest at any stage of venture development as they seek opportunities that produce a return in the foreseeable future.

Despite ongoing concern about the lack of venture-backed initial public offerings (IPOs), venture investment held steady at $7.4 billion in the second quarter of 2008, according to the Moneytree Report published by PricewaterhouseCoopers and the National Venture Capital Association (NVCA) based on data provided by Thompson Reuters.

According to National Science Foundation (NSF) data released two weeks ago, companies spent in aggregate $247.7 billion on R&D expenditures performed in the U.S. in 2006. Leading the nation was California, with $58.4 billion in industrial R&D, followed by Michigan ($16.5 billion), Massachusetts ($15.6 billion), New Jersey ($14.6 billion), and Texas ($13.3 billion).
 

Federal funding of academic science and engineering (S&E) R&D failed to outpace inflation for two consecutive years, according to the latest annual Survey of Research and Development Expenditures at Universities and Colleges from the National Science Foundation (NSF).  The decline in two consecutive years has never occurred before in the survey's 36-year history.

Even in the venture capital-rich state of California during a boom period for clean energy investment, some clean energy entrepreneurs still have a hard time finding the capital resources they desire. As a result, one non-profit venture capital group, with a unique history of its own, is launching a new effort to support early-stage businesses. The California Clean Energy Fund (CalCEF) is currently helping to raise a $20 million angel fund to bridge a perceived gap in seed and start-up stage capital availability.

As many stories in this issue of the Digest point out, academic institutions serve a critical role in performing R&D for the nation’s innovation pipeline. While most of the attention of national policymakers is directed toward the size of federal and industrial investments in R&D, the burden of financing the infrastructure to support much of that research activity falls on states and institutions of higher education. And that burden has a steep price tag.

The National Institutes of Health (NIH) have announced a four-year plan to invest approximately $70 million a year in a nationwide network of life science research centers. The Molecular Libraries Probe Production Centers Network will employ high-tech screening methods to identify molecules that can be used as probes to explore the functions of cells. This research is intended to help increase the pace of discovery in the field of chemical probes, which have become a key resource in fighting disease.

The demand for highly qualified talent in Massachusetts' bioscience industry will add more than 10,000 life sciences workers to the state's workforce by 2014, according to a recent report prepared by the University of Massachusetts Donahue Institute.

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Still no sign of improvement as the U.S. enters the third quarter of its initial public offering (IPO) drought.  Just one venture-backed company made an IPO exit in the third quarter of 2008, according to a release from Thomson Reuters and the National Venture Capital Association (NVCA).

For several years governors across the country have announced life science and biotech initiatives that are as broad as they are large. The devil is in the details, and in most cases related to bio-based economic development, so are the opportunities.

The National Science Foundation (NSF) announced earlier this month the establishment of five new university-based centers developing interdisciplinary research and education programs in partnership with industry in the areas of biorenewable chemicals, green energy systems, communications networks, medical implants and smart lighting.

In the 2002 report Signs of Life: The Growth of Biotechnology Centers in the U.S., Joseph Cortright and Heike Mayer suggested it would take more than a decade for biotech investment strategies to yield fruit  - as measured by NIH funding and biocommercialization efforts.

Venture capitalists invested $7.1 billion in companies during the third quarter of 2008, according to the latest Moneytree survey from PricewaterhouseCoopers and the National Venture Capital Association (NVCA). Though this figure represents a nine percent decline from the same period last year, investment levels still show little evidence of the current drought in venture-backed exits.

Universities in Canada are a major component of the country's science and technology ecosystem, and as gauged by funding, they performed 36 percent of Canada's R&D activities in 2007. In the U.S. comparatively, universities accounted for 13 percent of the R&D performed in the country.

SSTI has prepared a table displaying the amount of funding companies spent on R&D in each state from 2002 to 2006, the state's rank in 2006, the percent change over this five-year period, and the rank of that percent change. For the U.S.

North Carolina's $1.2 billion dollar investment in bioscience over the past decade has helped to build a $45 billion dollar a year industry in the state, according to a new study released by the North Carolina Biotechnology Center. The report finds that North Carolina's bioscience employment numbers have grown 18.5 percent since 2001, the fastest in the nation.

The Montana Department of Commerce has announced that it will provide $2.5 million in grants to support bio-medical research. Montana-based, private nonprofit research institutions are eligible to apply for the funding, which may be used to expand, renovate and purchase equipment for biomedical research. The grants also may be used to expand infrastructure that will enhance scientific collaborations within the Montana University System.

In 2008, the U.S. ranked 17th in R&D tax generosity out of the 21 OECD countries that offered some form of R&D tax credits to businesses, according to a recent brief put out by the Information Technology & Innovation Foundation (ITIF). In U.S. Continues to Tread Water in Global R&D Tax Incentives, authors Rob Atkinson and Scott Andes state even though the U.S.

U.S. patent activity increased in 2009, after two years of reduced activity, according to statistics from the U.S. Patent and Trademark Office (USPTO). U.S. applicants were awarded 95,037 patents in 2009, up from 92,001 in 2008. Last year marked a return to the patenting levels of the early part of the decade, though in 2006 the country had hit an anomalous all-time high with 102,267 patents.

Often credited with contributing significant revenue to states' economies, research parks also house facilities for workforce training and provide resources for tech-based industries, which is especially important as the nation's employment begins to pick up steam. In West Virginia, officials are building a $15 million advanced technology-training center at the state-owned research and technology park, and in Utah, officials recently broke ground on a building that will house engineers and analysts working on the nation's Intercontinental Ballistic Missile program.

ASAIO, the oldest society in the world focusing on medical devices, is seeking device developers who are early in development (pre-seed/seed stage funding) to submit abstracts to the New Ventures Forum (NVF). The NVF is based on a partnership between ASAIO and students from MIT Sloan School of Business that seeks to provide a forum for the presentation of next generation medical devices and a robust discussion of the commercialization challenges these technologies may encounter.