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Even in the venture capital-rich state of California during a boom period for clean energy investment, some clean energy entrepreneurs still have a hard time finding the capital resources they desire. As a result, one non-profit venture capital group, with a unique history of its own, is launching a new effort to support early-stage businesses. The California Clean Energy Fund (CalCEF) is currently helping to raise a $20 million angel fund to bridge a perceived gap in seed and start-up stage capital availability.

As many stories in this issue of the Digest point out, academic institutions serve a critical role in performing R&D for the nation’s innovation pipeline. While most of the attention of national policymakers is directed toward the size of federal and industrial investments in R&D, the burden of financing the infrastructure to support much of that research activity falls on states and institutions of higher education. And that burden has a steep price tag.

The National Institutes of Health (NIH) have announced a four-year plan to invest approximately $70 million a year in a nationwide network of life science research centers. The Molecular Libraries Probe Production Centers Network will employ high-tech screening methods to identify molecules that can be used as probes to explore the functions of cells. This research is intended to help increase the pace of discovery in the field of chemical probes, which have become a key resource in fighting disease.

The demand for highly qualified talent in Massachusetts' bioscience industry will add more than 10,000 life sciences workers to the state's workforce by 2014, according to a recent report prepared by the University of Massachusetts Donahue Institute.

John Hindman announced his resignation as secretary of the Kentucky Cabinet for Economic Development.

Governor Rick Perry recently announced Alan Kirchhoff of Austin has been promoted to director of Texas Emerging Technology Fund (TETF). Kirchhoff replaces longtime Perry advisor and former TETF director Mark Ellison, who left the Governor's Office to become associate vice chancellor of economic development for the Texas A&M University System beginning Oct. 1, 2008.

Complete descriptions of these opportunities and others are available at http://www.ssti.org/posting.htm.

Complete descriptions of these opportunities and others are available at http://www.ssti.org/posting.htm.

SSTI has an effective new learning tool for TBED policymakers and practitioners seeking guidance in approaches to building and sustaining tech-based economies. Through exclusive interviews with Excellence in TBED Award recipients, find out first-hand how these award winning initiatives successfully responded to a critical need by applying innovative approaches to generate substantial economic gains for their region.

Bank bailouts may be capturing all of the headlines, but a new initiative from the European Union (EU) promises to inject a considerable pool of money during the downturn to accelerate the development of hydrogen and fuel cell technologies. The European Commission, as well as participants from the European research community and industry will contribute nearly 1 billion Euros (U.S. $1.28 billion) to the public-private partnership over the next six years to fund research.

Still no sign of improvement as the U.S. enters the third quarter of its initial public offering (IPO) drought.  Just one venture-backed company made an IPO exit in the third quarter of 2008, according to a release from Thomson Reuters and the National Venture Capital Association (NVCA).

For several years governors across the country have announced life science and biotech initiatives that are as broad as they are large. The devil is in the details, and in most cases related to bio-based economic development, so are the opportunities.

The National Science Foundation (NSF) announced earlier this month the establishment of five new university-based centers developing interdisciplinary research and education programs in partnership with industry in the areas of biorenewable chemicals, green energy systems, communications networks, medical implants and smart lighting.

Complete descriptions of these opportunities and others are available at http://www.ssti.org/posting.htm.

While the Presidential election takes center stage on November 4, voters in several states also will cast their votes on statewide ballot issues affecting the TBED community. In addition to the 11 gubernatorial races and more than 5,800 state legislative seats up for grabs, voters across the nation will consider measures to provide funding for public education, expand investment in alternative and renewable energy, lift restrictions on stem-cell research, and eliminate income tax and state spending caps.

In the 2002 report Signs of Life: The Growth of Biotechnology Centers in the U.S., Joseph Cortright and Heike Mayer suggested it would take more than a decade for biotech investment strategies to yield fruit  - as measured by NIH funding and biocommercialization efforts.

Southern Growth hired Ted Abernathy, Jr., former Executive Vice President & COO of the Research Triangle Regional Partnership, to serve as its Executive Director, filling the vacancy created by Jim Clinton's resignation in September.

After two years of campaigning, President-elect Barack Obama has begun shaping the agenda for his coming administration. Though nothing is certain at this point, throughout his campaign, President-elect Obama reiterated his support for TBED-related initiatives and plans to increase funding for research and innovation.

The outcome of Tuesday's election resulted in several wins and some defeats for TBED among the more than 150 ballot measures presented to voters across the nation. Outlined below are the unofficial election results of select ballot measures from each state's respective election office and local media reports as of Wednesday, Nov. 5.

Eleven gubernatorial elections were held across the U.S. on Tuesday, resulting in the selection of three new governors - with TBED initiatives spread throughout their campaigns' messages.

Democrats took control of five legislative chambers in Tuesday's elections: Delaware House, Nevada Senate, New York Senate, Ohio House, and Wisconsin Assembly.

Venture capitalists invested $7.1 billion in companies during the third quarter of 2008, according to the latest Moneytree survey from PricewaterhouseCoopers and the National Venture Capital Association (NVCA). Though this figure represents a nine percent decline from the same period last year, investment levels still show little evidence of the current drought in venture-backed exits.

Universities in Canada are a major component of the country's science and technology ecosystem, and as gauged by funding, they performed 36 percent of Canada's R&D activities in 2007. In the U.S. comparatively, universities accounted for 13 percent of the R&D performed in the country.

SSTI has prepared a table displaying the amount of funding companies spent on R&D in each state from 2002 to 2006, the state's rank in 2006, the percent change over this five-year period, and the rank of that percent change. For the U.S.

To attract and grow high technology businesses and streamline its economic development efforts, a task force created in 2007 to study economic competitiveness in Arkansas recommends the state remove its constitutional prohibition on state equity investments in priva