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As the global economy continues to struggle through the COVID-19 pandemic, the National Institutes of Health (NIH) has released an interactive online tool for discovering success stories of small business innovation and entrepreneurship. Showcasing several of the businesses that have successfully leveraged NIH small business funding — totaling more than $1 billion annually — to develop healthcare products and services, NIH’s Small Business Education and Entrepreneurial Development (SEED) office hopes that the tool will inspire others to start businesses and develop their technologies.

The NIH’s High-Risk, High-Reward Research program (HRHR) has the potential to overturn fundamental paradigms, but historically the applicant and awardee pools have not fully represented the demographic and geographic diversity across the U.S. biomedical workforce, says the NIH’s deputy director for extramural research. Those concerns, and others about bias in the peer review process, have led to a new approach — the HRHR program is going to anonymize the review of the Transformative Research Award applications.

The most recently-passed federal legislation to address COVID-19 included funding for the National Institutes of Health (NIH) and the Biomedical Advanced Research and Development Authority (BARDA) to accelerate testing. The provision, added by Sens. Roy Blunt and Lamar Alexander, was envisioned to take an approach similar to TV’s “Shark Tank.” NIH is implementing the funds as a three-phase, “Rapid Acceleration of Diagnostics (RADx),” challenge with up to $500 million in prizes. Teams with COVID-19 testing solutions will submit proposals, which will be evaluated by experts from the five hubs of NIH’s Point-of-Care Technologies Research Network. Finalists will receive assistance from experts before the final selection is made.

In this week’s edition of Useful Stats, we take a look at NIH’s SBIR/STTR program by state, including the success rate of applications, the share SBIR awards make up of NIH funding to for-profit companies by state, and the total number of awards by state. It should be noted that SSTI was able to prepare this information because of the excellent transparency of information that NIH offers on its website, a model that should be replicated by other federal agencies.

For the first time and in response to the COVID-19 outbreak, the National Institute of Allergy and Infectious Diseases (NIAID) together with the National Institute of General Medical Sciences (NIGMS) has activated the NIH Urgent Award mechanism. The targeted opportunity is intended to provide funds for NIH grantees applying to expand the scope of their active grant. Last month, NIAID and NIGMS published a Notice of Special Interest (NOSI) “to highlight the urgent need for research on the 2019 novel Coronavirus (2019-nCoV). NIAID is particularly interested in projects focusing on viral natural history, pathogenicity, transmission, as well as projects developing medical countermeasures and suitable animal models for pre-clinical testing of vaccines and therapeutics against 2019-nCoV.”

NIH has taken an expanded approach in defining scientists from disadvantaged backgrounds, in an effort to encourage and enable more biomedical scientists. NIH determined that the criteria they were using in defining disadvantaged was too narrow; for example, what was considered low-income ($25,750 for a family of four) is actually considered severe poverty and represents an overly strict threshold, the reviewers found. They have issued new guidelines and will consider scientists to have come from a disadvantaged background if they meet at least two criteria from their expanded list, including no parents or legal guardians who completed a bachelor’s degree, past eligibility for the federal free and reduced lunch program for two or more years, and were or are currently eligible for federal Pell grants.

In recent weeks, three separate reviews of R&D grants and awards at NIH have shed new light on issues of minority and women representation among researchers and on potential conflicts of interest by investigators. NIH has been publicly working to address concerns about representation and trustworthiness among its investigators. While the results from these studies show that the agency has more work to do, the availability of this information speaks favorably to NIH's transparent approach to these conversations. 

Home to the Research Triangle Park and top-tier research universities like Duke University and the University of North Carolina at Chapel Hill, the Durham-Chapel Hill metropolitan area led all regions in per capita NIH funding in FY 2018 and placed sixth in total funding that year, according to a new analysis by SSTI. This edition of Useful Stats looks at all NIH awards at the regional level over the five-year period between FY 2014 and FY 2018. Boston led all regions in total NIH funding in FY 2018, while NIH funding in the Washington, D.C., region increased by the greatest percentage over the five-year period among major metropolitan areas.

As the largest public funder of biomedical research in the world, NIH awards are of particular importance to the technology-based economic development community. Including new data for FY 2017 and FY 2018, this edition of Useful Stats serves as an update to an August 2017 article highlighting NIH awards by state over the past decade. In FY 2018, NIH awarded a total of $28.3 billion in funds to the 50 states and territories. Of the total amount awarded in 2018, slightly less than two thirds (65.3 percent) went to the top 10 states. This share is slightly lower than in 2017 (65.6 percent), the same as in 2014 (65.3 percent) and slightly higher than in 2009 (66.1 percent).

Are you looking to increase the success rate of your state’s SBIR/STTR proposals? If so, a reminder that applications for the Small Business Administration’s Federal and State Technology (FAST) Partnership Program are due next Friday, June 28, at 4 p.m. EDT. This program provides one-year funding to organizations executing programs related to SBIR/STTR outreach, technical assistance, or financial support. As a way to help inform these proposals, SSTI has updated the data from a January Useful Stats article on NIH SBIR/STTR success rates to include the most recent year available, FY 2018.