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The U.S. Department of Commerce recently announced that the agency formerly known as the U.S. AI Safety Institute has been renamed the Center for AI Standards and Innovation (CAISI). The center’s priority focus areas also have been adjusted so that CAISI can serve as industry’s primary point of contact within the U.S. Government to facilitate testing and collaborative research. According to the Commerce announcement, CAISI will:

The U.S. Small Business Administration posted a notice in the June 9, 2025, Federal Register of SBA’s intent to establish a Manufacturing in America Advisory Committee to “provide strategic guidance, advice, and recommendations to the U.S. government and relevant stakeholders on matters related to growth, supply chain resilience, and innovation of small manufacturing businesses across the country. The committee will act as the collaborative body to ensure the sector's needs, challenges, and opportunities are addressed.

With Q1 2025 venture capital (VC) data stabilized and reports coming out on investment activity, it is a good time to review 2025 VC investment from a TBED perspective. Many published reports on VC activity include deals at the top end of the size range that—with individual transactions now reaching- billions of dollars—can swing some of the metrics and mask the underlying nuances facing smaller companies and markets. While investment levels are trending up, the totals are driven by mega deals and AI companies.

Many SSTI members will attend the annual BIO International Convention, which will be held this year in Boston from June 16 to 19. There, they join a cohort of organizations with various connections to the life sciences, including contract research and manufacturing companies, academic centers, "big" pharma, "little" pharma, and foreign nations representing their life sciences efforts. 

In fiscal year (FY) 2023, federal obligations for science and engineering (S&E) to universities and colleges totaled $49 billion—$29 billion more than FY 2000, and a 10% increase from the prior year. The growth is less rapid when adjusted for inflation (2017 USD), with just over $40 billion in real obligations in FY 2023, a 5% increase over the year prior and $12.6 billion (or 46%) increase over the FY 2000 value.

The Australian Strategic Policy Institute’s (ASPI) report, ASPI’s two-decade Critical
Technology Tracker: The rewards of long-term research investment, aims to identify
which countries and institutions are leading in high-impact research across 64 critical
technological domains, including defense, space, energy, environment, artificial

The New York City Economic Development Corporation (NYCEDC) recently announced that it is awarding Fordham University $3 million from its Greenlight Innovation Fund. The university will also receive additional funds, including a $1.1 million grant from Councilman Oswald Feliz, to create the Bronx Green Job Center (BGJC), a workforce development and entrepreneurship hub that aims to create an equitable green-job pipeline in the Bronx.

July 29
3:00 p.m. EDT
Free

Please join us for the Innovation Finance subcommunity meeting where we will discuss Innovation Finance 101. This meeting is intended to be the first in a series of foundational conversations on innovation finance and will focus on the terminology, process, and structure of venture capital investment. Register here. 

As policymakers consider how to invest limited dollars to stimulate R&D across the U.S. while other countries increase their investments, it’s important to examine whether newer regional policy approaches have the potential to increase national competitiveness versus traditional individual programs.

Vaccine and therapeutics storage and delivery may never be the same as Emory University and Micron Biomedical recently announced the first clinical trial of a novel rotavirus vaccine, CC24, delivered via dissolvable microarray technology. This clinical trial was the first clinical evaluation of any drug or vaccine delivered via patch or microarray that is sponsored by the U.S. Centers for Disease Control and Prevention (CDC). 

Massachusetts’ Gov. Maura Healey recently proposed a multi-year funding strategy (Five-Year Massachusetts Capital Investment Plan (CIP) [FYs 2026-2030] that  would include investment of $890.4 million, including general obligation bonds and private sector contributions, for many of the state’s TBED and innovation initiatives (programs are outlined below).

The Opportunity Zone (OZ) program, first established in 2017 with a ten-year lifespan, has been made permanent in Public Law No: 119-21. As noted in a 

After the tremendous learning and community-building experience at SSTI’s conference last December at the beautiful Sheraton at Wild Horse Pass in Arizona, many people are looking forward to our next gathering. We are too, but have decided to postpone the event until next year with dates to be determined.

The U.S. Small Business Administration announced a new funding opportunity through the Regional Innovation Cluster (RIC) Program. The program is designed to enable new RICs to assist small businesses in matching innovative technologies to industry needs, with the aim of reshoring critical industrial and manufacturing capabilities, securing domestic supply chains, and spurring job creation.

SBA is interested in competitive offers from organizations with relevant partnerships and small business expertise in critical industries, including: 

How one applies and has their proposal reviewed to gain a small share of the world's largest funding source for life science research is changing. The following highlights modifications affecting grant applications submitted to the National Institutes of Health for due dates on or after January 25, 2025, as posted on their Implementation of New Initiatives and Policies page.

The April 2025 issue of NBER Digest, a publication of the National Bureau of Economic Research, includes the following summary of a recent working paper. NBER grants permission to reproduce the piece here. While the research focuses on students’ experiences only in Texas, SSTI believes the findings likely could have policy value in other geographies striving to increase workers’ skill sets in an increasingly innovation driven economy.

States with economies based on resource extraction are among the least diversified in the country—they know well the boom-and-bust cycles that come with that concentration.

Gov.

Numerous reports across the country indicate the National Institute of Standards and Technology (NIST) has taken the first step toward eliminating the Manufacturing Extension Partnership (MEP) program, which, for nearly 40 years, has provided technical assistance, training, research and strategic direction to tens of thousands of small and medium manufacturers across the country. Reports vary as to whether 10 or 11 of the 51 centers across the U.S.

With President Trump’s March 31 signature on an executive order to create a United States Investment Accelerator within the Department of Commerce aimed to help expedite development of foreign and domestic manufacturing investments priced at over $1 Billion, there is concern about what impact one sentence has on the existing $52 Billion in CHIPs related deals across the country. Some of the projects have been on ice since the change of Administration. 

Imagine tapping into a talent pool already familiar with your region's culture, values, and challenges. This scenario is the core idea behind affinity recruiting, a strategy where communities and businesses actively target former residents, alums, and individuals with a genuine connection to the area. These initiatives aim to entice them for job opportunities, entrepreneurial ventures, leadership roles, or investment.

The U.S. Census Bureau’s Narrative Profiles is an online resource that presents American Community Survey (ACS) 5-year estimates as easily digestible analytic reports.

Exploring gross domestic product (GDP) at the county level offers a more detailed look at where industries are located and how they shape local economies, especially in smaller or more rural counties often overlooked at higher geographic levels.

A handful of showcase events across the country are known widely by mere nicknames, gather lots of media attention, and attract tens of thousands of people or more each year. Can a state’s lead technology-based economic development stand out in this kind of crowd? Is it worth the investment to try? 

Recognizing Louisiana’s lag in some prosperity metrics, loss of talent over the past decade, and need to build a more competitive economy among its southern state peers, the Louisiana Economic Development (LED) has created a strategic plan that emphasizes innovation, technology, and entrepreneurship as the means to address the challenges and opportunities it faces in creating a more robust and talent-attracting economy.