America's Seed Fund returns to the J.W. Marriott in Austin, Texas, for the SBIR/STTR Spring Innovation Conference from June 9 -11.  SSTI Weekly Digest readers may use these discount codes to reduce their cost for attending:

SSTI has recently expanded its staff to include Aaron Hagar as their vice president for innovation finance. Hagar brings over twenty years of experience spanning biomedical research, heath care, public policy, and technology-based economic development to share with SSTI's members. He has significant experience building partnerships, creating innovative solutions, shaping public policy, and developing data-driven strategies.

The SSTI Board of Trustees has appointed Kristy Campbell, president & chief operations officer at Rev1 Ventures, and John Fernandez, chief executive officer at The Mill, as members of the board.  “I look forward to working with Kristy and John as new board members,” Dan Berglund, SSTI’s president, said with their appointments. “Both are proven, inspiring leaders, have been long time friends of SSTI, and demonstrated strong commitments to advancing the TBED community.”

The United States faces intense competition in global markets for advanced technology industries.

The White House Fiscal Year 2026 discretionary budget proposal outlines a significant shift in federal spending priorities, proposing substantial reductions in innovation and non-defense discretionary funding, which, if enacted by Congress, would impact scientific research and regional economic development support across numerous federal agencies. 

In 1978, Massachusetts took a risk and made an $8.5 million investment into one of the earliest technology-based economic development (TBED) initiatives in the world. The commonwealth, among the states hard-hit by the global manufacturing restructuring underway at the time, which led to the deep recession of the early 80s, knew it needed to try something different to restore its economy and its long-term competitiveness.

The U.S. Department of Commerce recently announced that the agency formerly known as the U.S. AI Safety Institute has been renamed the Center for AI Standards and Innovation (CAISI). The center’s priority focus areas also have been adjusted so that CAISI can serve as industry’s primary point of contact within the U.S. Government to facilitate testing and collaborative research. According to the Commerce announcement, CAISI will:

The U.S. Small Business Administration posted a notice in the June 9, 2025, Federal Register of SBA’s intent to establish a Manufacturing in America Advisory Committee to “provide strategic guidance, advice, and recommendations to the U.S. government and relevant stakeholders on matters related to growth, supply chain resilience, and innovation of small manufacturing businesses across the country. The committee will act as the collaborative body to ensure the sector's needs, challenges, and opportunities are addressed.

With Q1 2025 venture capital (VC) data stabilized and reports coming out on investment activity, it is a good time to review 2025 VC investment from a TBED perspective. Many published reports on VC activity include deals at the top end of the size range that—with individual transactions now reaching- billions of dollars—can swing some of the metrics and mask the underlying nuances facing smaller companies and markets. While investment levels are trending up, the totals are driven by mega deals and AI companies.

Many SSTI members will attend the annual BIO International Convention, which will be held this year in Boston from June 16 to 19. There, they join a cohort of organizations with various connections to the life sciences, including contract research and manufacturing companies, academic centers, "big" pharma, "little" pharma, and foreign nations representing their life sciences efforts. 

In fiscal year (FY) 2023, federal obligations for science and engineering (S&E) to universities and colleges totaled $49 billion—$29 billion more than FY 2000, and a 10% increase from the prior year. The growth is less rapid when adjusted for inflation (2017 USD), with just over $40 billion in real obligations in FY 2023, a 5% increase over the year prior and $12.6 billion (or 46%) increase over the FY 2000 value.

The Australian Strategic Policy Institute’s (ASPI) report, ASPI’s two-decade Critical
Technology Tracker: The rewards of long-term research investment, aims to identify
which countries and institutions are leading in high-impact research across 64 critical
technological domains, including defense, space, energy, environment, artificial

For the United States to achieve greater security in chip manufacturing, the critical sector requires a much larger, better trained workforce.

If you’re leading a knowledge work[1] organization and considering introducing generative artificial intelligence into your workflow, it likely would be helpful to know how its use may impact the day-to-day aspects of your team’s work, and the potential risks involved. 

Note: TBED101 is a new, occasional series for Digest readers visiting and revisiting fundamental topics for nurturing strong regional innovation economies. SSTI is introducing this series, with EDA support, as the field has entered one of its most significant periods of disruption and change in its 45-year history.