Vaccine and therapeutics storage and delivery may never be the same as Emory University and Micron Biomedical recently announced the first clinical trial of a novel rotavirus vaccine, CC24, delivered via dissolvable microarray technology. This clinical trial was the first clinical evaluation of any drug or vaccine delivered via patch or microarray that is sponsored by the U.S. Centers for Disease Control and Prevention (CDC). 

Massachusetts’ Gov. Maura Healey recently proposed a multi-year funding strategy (Five-Year Massachusetts Capital Investment Plan (CIP) [FYs 2026-2030] that  would include investment of $890.4 million, including general obligation bonds and private sector contributions, for many of the state’s TBED and innovation initiatives (programs are outlined below).

The Opportunity Zone (OZ) program, first established in 2017 with a ten-year lifespan, has been made permanent in Public Law No: 119-21. As noted in a 

After the tremendous learning and community-building experience at SSTI’s conference last December at the beautiful Sheraton at Wild Horse Pass in Arizona, many people are looking forward to our next gathering. We are too, but have decided to postpone the event until next year with dates to be determined.

The U.S. Small Business Administration announced a new funding opportunity through the Regional Innovation Cluster (RIC) Program. The program is designed to enable new RICs to assist small businesses in matching innovative technologies to industry needs, with the aim of reshoring critical industrial and manufacturing capabilities, securing domestic supply chains, and spurring job creation.

SBA is interested in competitive offers from organizations with relevant partnerships and small business expertise in critical industries, including: 

The U.S. Small Business Administration adopted new rules in 2023 that made it easier for venture capital funds to leverage federal resources under the Small Business Investment Company (SBIC) program, thereby increasing the capital they have available for early-stage investments.

The nearly status quo nature of the FY 2026 budget of $9.0 billion for the National Science Foundation advanced by the Senate Appropriations Committee stands in striking contrast to the Administration’s $3.9 billion request. House appropriations, meanwhile, appropriated $7.0 billion for NSF, a reduction of $2.06 billion or 23% from the FY 2025 enacted level.

The Financial Services and General Government (FSGG) subcommittee of House Appropriations has turned against the Federal and State Technology (FAST) Partnership in its budget recommendations for the Small Business Administration, zeroing out the only program that provides funds to help states level the competitive field of applicants for the SBIR/STTR program. While the FAST funds were decreased from the $9 million enacted in FY2024, the SBDC line item received a $10 million increase in the FSGG appropriations proposal.

House and Senate subcommittees with oversight for Commerce, State and Justice appropriations differ on funding recommendations for the EDA Regional Technology and Innovation Hubs program, commonly referred to as Tech Hubs. While any funding in a tight budget environment is good, the $50 million in the House version of the CJS bill or the Senate subcommittee’s $60 million is far short of Congress’s original vision for the Tech Hubs, authorized at $10 billion over ten years.

In perhaps the most difficult budget season of the last 25 years, where the President’s budget has proposed eliminating funding for scores of programs, both the House and Senate subcommittees with budget oversight for the Economic Development Administration (EDA) have proposed continuation funding of $50 million for FY2026 for the popular Build 2 Scale (B2S) program—referred to as the Regional Innovation Program Grants in budget language.

As attention-grabbing as AI might be for the media and large investors (see previous SSTI analysis of AI investment), economic growth through innovation in life sciences and biotechnology is a priority for many state and regional TBED initiatives.  The venture capital market recognizes that as well.

Understanding the composition of local economies requires looking beyond broad statewide or national trends. County-level data reveals the unique mix, or lack thereof, of industries and businesses in each area. Policy makers, by identifying which sectors drive employment and business activity within a locality, can influence the impact and design of regional innovation strategies to reflect local realities and potential.  

As the end of the fiscal year approaches, Congress is again at a critical juncture in reauthorizing the SBIR and STTR programs.