With Q1 2025 venture capital (VC) data stabilized and reports coming out on investment activity, it is a good time to review 2025 VC investment from a TBED perspective. Many published reports on VC activity include deals at the top end of the size range that—with individual transactions now reaching- billions of dollars—can swing some of the metrics and mask the underlying nuances facing smaller companies and markets. While investment levels are trending up, the totals are driven by mega deals and AI companies.

Many SSTI members will attend the annual BIO International Convention, which will be held this year in Boston from June 16 to 19. There, they join a cohort of organizations with various connections to the life sciences, including contract research and manufacturing companies, academic centers, "big" pharma, "little" pharma, and foreign nations representing their life sciences efforts. 

In fiscal year (FY) 2023, federal obligations for science and engineering (S&E) to universities and colleges totaled $49 billion—$29 billion more than FY 2000, and a 10% increase from the prior year. The growth is less rapid when adjusted for inflation (2017 USD), with just over $40 billion in real obligations in FY 2023, a 5% increase over the year prior and $12.6 billion (or 46%) increase over the FY 2000 value.

The Australian Strategic Policy Institute’s (ASPI) report, ASPI’s two-decade Critical
Technology Tracker: The rewards of long-term research investment, aims to identify
which countries and institutions are leading in high-impact research across 64 critical
technological domains, including defense, space, energy, environment, artificial

The U.S. National Science Foundation (NSF) is requesting information from the public to help shape potential future updates to its Key Technology Focus Areas (KTFAs). NSF’s KTFAs directly influence and shape innovation- and economic development-related programs.

SSTI has updated its Key Technology Area Investment Data Tool with new and refreshed data spanning January 1, 2013, through June 30, 2025. The tool comprises two interactive visuals and uses Pitchbook technology verticals selected to align with many of the key technology focus areas (KTFAs) defined in the CHIPS and Science Act of 2022 (CHIPS).

Over the past 40 years, many people involved in SBIR and empirical analysts in the research, finance, and technology sectors have said SBIR awardees, as a group, are uniquely important for America’s innovation goals.

Please note: this article is not intended as a comprehensive review of Public Law No. 119-21, nor should our reading of the law be treated as tax or legal advice.

The overlap between applicants and recipients of the three large regional innovation approaches attempted by the federal government so far continues with the July 9, 2025, NSF narrowing of the field for the second NSF Regional Innovation Engines competition to 29 semifinalists across the country.

The Q3 2025 investment data is in, and trends of fewer deals and more dollars continue.

With federal R&D investments unlikely to keep pace with inflation or international competition based on the administration’s budget request, cuts to existing research grants, and Congress’s inability to pass a budget, business R&D investments become more critical for sustaining the competitiveness of regional innovation economies.

Note: The research careers for this year’s triple winners support the underlying arguments for public involvement in technology-based economic development. Well-designed and sustained public-private regional innovation initiatives—the work of SSTI and its member organizations—can make a positive difference for local competitiveness.